The purpose of this research work was to improve the solubility and dissolution rate of the telmisartan by dispersing drug in nanoparticles form in water soluble polymer at pH 7.5 (FDA recommended) using various nanodispersion techniques. Nanodispersion of telmisartan were prepared using PVP-K30 by various methods like solvent evaporation, antisolvent precipitation and spray drying in ratios 1:1 to 1:4. Saturation solubility, in-vitro dissolution, particle size distribution, FT-IR spectroscopy, PXRD, DSC and SEM studies were carried out. The results indicated that formulation containing 1:4 ratio of drug: PVP-K30 prepared by spray drying method showed the cumulative release of 99.84 % as compared to 9.36 % for the pure drug in pH 7.5 phosphate buffer and more than 100 times increases in solubility. Particle size analysis reveals that Telmisartan was dispersed in the form of nanoparticles into the PVP matrix with particles with sizes smaller than 5–10 nm. X-ray diffraction, differential scanning calorimetry and Fourier transform infrared characterization indicated the nanodispersion exhibited change in crystalline nature. Nanodispersion has been successfully formulated avoiding the need for surfactant, basic amino acid, solubilising agents like alkali hydroxide uses during formulation, there by simplifying the techniques.
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